ULK 1 translocates to mitochondria and phosphorylates FUNDC 1 to regulate mitophagy
نویسندگان
چکیده
منابع مشابه
ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy.
Autophagy eliminates dysfunctional mitochondria in an intricate process known as mitophagy. ULK1 is critical for the induction of autophagy, but its substrate(s) and mechanism of action in mitophagy remain unclear. Here, we show that ULK1 is upregulated and translocates to fragmented mitochondria upon mitophagy induction by either hypoxia or mitochondrial uncouplers. At mitochondria, ULK1 inter...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2014
ISSN: 1469-221X,1469-3178
DOI: 10.1002/embr.201438501